research
The research of the group is based on chemical synthesis. We focus on the development of novel methods for the synthesis of small compounds and following application of the developed reaction methodology for preparation of focused compound libraries. Obtained compounds are studied using cell based assays and chemical genetic approaches to evaluate possible targets. Furthermore, we are elaborating new synthetic strategies for the preparation of complex lead molecules with pronounced bioactivity.
The group’s research covers several complementary areas of organic synthesis for the development of novel efficient reaction methodology, such as:
• Enantioselective catalysis for the synthesis of complex chiral products with multiple stereocenters
• C-H bond activation using transition metal catalysis for direct coupling of non-functionalized compounds
• C-H bond functionalization based on utilization of direct oxidative metal-free methods for synthesis of compounds of interest
